Chemistry Forum

I've been performing analysis on croscarmellose sodium to the European pharmacopoeia and don't quite understand how the calculation works. Can anyone help?

I have not the exact answer, but we think that to obtain the good milliequivalents of base, we should add the 25 mL initially added to the x mL of the titration minus the total mL of acid

Maybe this reference will help
http://www.scielo.br/scielo.php?pid=S01 ... xt&tlng=en
In any case titration should be not much different from titration of sodium acetate except you should allow material to swell and fully penetrate acid into the material during titration.