Degree of Substitution

sarahm2008 · Post by **sarahm2008** » Thu Dec 04, 2008 2:28 pm

I've been performing analysis on croscarmellose sodium to the European pharmacopoeia and don't quite understand how the calculation works. Can anyone help?

henri breguiboul · Post by **henri breguiboul** » Mon Mar 16, 2009 8:55 am

I have not the exact answer, but we think that to obtain the good milliequivalents of base, we should add the 25 mL initially added to the x mL of the titration minus the total mL of acid

expert · Post by **expert** » Wed Mar 18, 2009 10:34 pm

Maybe this reference will help
http://www.scielo.br/scielo.php?pid=S01 ... xt&tlng=en
In any case titration should be not much different from titration of sodium acetate except you should allow material to swell and fully penetrate acid into the material during titration.