Chemistry Forum

I would like to know where can I find a 10L 20L equipment for solid phase peptide synthesis.

I see Buchi brand design is great, but the price is too high. I find this model looks nice and pirce is acceptable but I need more options.

If somebody is working in industry as production chemist please help me.

PeptiSystems' PeptiPilot may be the right choice. It is a compact, fully automated SPPS system designed for small-scale production and process development. The system supports up to 12 mmol and uses flow-through column technology, allowing efficient synthesis with reduced solvent consumption. The system is more cost-effective than traditional batch reactors and is suitable for scale-up to larger systems such as PeptiPr

Biotage provides a wide range of SPPS equipment, including automated synthesizers, reactors, and workstations. While they offer smaller scales, some models can handle larger volumes, and they are known for their good cost-to-performance ratio.

Reaction Vessels: These are crucial for containing the resin and reagents during synthesis. They come in various sizes and materials, including glass and polypropylene.

For large-scale solid-phase peptide synthesis (SPPS) in the 10L to 20L range, PeptiSystems, AAPPTEC, and Chemglass Life Sciences offer good alternatives to Büchi at more affordable prices. PeptiSystems provides automated flow-through synthesizers for GMP and non-GMP production. AAPPTEC specializes in pharmaceutical-grade peptide synthesizers with scalable options. Chemglass offers filter reactors suitable for SPPS, allowing multi-step reactions in the same vessel. It’s best to contact manufacturers directly to compare features and pricing.