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The Steps for a Total Synthesis

Posted: Wed Aug 07, 2024 3:55 pm
by Bastian123
What's the easiest and most efficient way to make this, anyone know?
Sodiumsulfhydrylacrylate.jpg

Re: The Steps for a Total Synthesis

Posted: Thu Aug 08, 2024 12:27 am
by ChenBeier
I would start with Cysteine. Elimination of the Aminogroup in alcaline condition.

Formal live

HSCH2CHNH2COOH + NaOH => HS-CH=CH-COONa + NH3 + H2O

But it needs some steps between.

Or start with 3-Bromoacrylicacid and sodiumhydrogensufide

Br-CH=CH-COOH + 2 NaSH => HS-CH=CH-COONa + NaBr + H2S

Re: The Steps for a Total Synthesis

Posted: Thu Aug 08, 2024 6:00 am
by Bastian123
This cystine route, can you go into some more detail please?
Is it possible to do this from acrylic acid?