Purification of volatile aldehydes
Posted: Wed Mar 08, 2017 9:44 am
Hey,
I am trying to get 4-pentenal from 4-penten-1-ol. Swern or DMP work but the work up/purification is the problem.
I want to use the newly formed aldehyde in a reaction involving LDA in the next step at -78°C so I need it to be in THF and not DCM.
Distillation usually lead to either the product decomposing or just making an azeotrope with DCM.
I am desperate for help, I thought of making trying to use a sodium bisulfite adduct but I would need to regenerate the aldehyde in THF and couldn't find conditions for that.
Any help would be greatly appreciated.
Kel.
I am trying to get 4-pentenal from 4-penten-1-ol. Swern or DMP work but the work up/purification is the problem.
I want to use the newly formed aldehyde in a reaction involving LDA in the next step at -78°C so I need it to be in THF and not DCM.
Distillation usually lead to either the product decomposing or just making an azeotrope with DCM.
I am desperate for help, I thought of making trying to use a sodium bisulfite adduct but I would need to regenerate the aldehyde in THF and couldn't find conditions for that.
Any help would be greatly appreciated.
Kel.