Is Ibuprofen soluble in 1.0 M NaOH?

zguitarmaster · Post by **zguitarmaster** » Tue Apr 10, 2007 8:54 pm

Thanks in advance

clarke Slemon · Post by **clarke Slemon** » Sat Apr 14, 2007 11:56 am

Ibuprofen is a lipophilic carboxylic acid. It will form a sodium salt in sodium hydroxide solution. Using an excess of sodium hydroxide however does not improve the solubility however but rather decreases the solubility.
This is caused by the common ion effect. The solubility product which is the limiting factor for solubility is a function of the total sodium ion concentration. Ibuprofen is more likely to be soluble in a stoichiometric amount of sodium hydroxide in water.