Metabolism of Metronidazole...inhibition by CO

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redfox
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Metabolism of Metronidazole...inhibition by CO

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I'm trying to write a report on something I don't really understand very well, despite having read up on related subjects and reagents involved.

Anaerobic bacteria were bubbled with CO and treated with Metronidazole. I have said that bacteria weren't killed as the environment was anaerobic, but cyt p450 was inhibited by the CO and so was unable to metabolise Metronidazole. However, the Metronidazole was metabolised and I have to find out why. I've suggested that epithelial cells present may have played a part but I'm not sure how exactly!

Can anyone offer a suggestion please?

Thanks:)
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