Micahel addition on amines containing thiols

Chemistry and homework help forum.

Organic Chemistry, Analytical Chemistry, Biochemistry, Physical Chemistry, Computational Chemistry, Theoretical Chemistry, High School Chemistry, Colledge Chemistry and University Chemistry Forum.

Share your chemistry ideas, discuss chemical problems, ask for help with scientific chemistry questions, inspire others by your chemistry vision!

Please feel free to start a scientific chemistry discussion here!

Discuss chemistry homework problems with experts!

Ask for help with chemical questions and help others with your chemistry knowledge!

Moderators: Xen, expert, ChenBeier

Post Reply
Posts: 1
Joined: Wed Aug 31, 2022 4:02 pm

Micahel addition on amines containing thiols

Post by notarinshallah »

I am an unholy biologist attempting to do some simple chemistry for the first time in my life. I wanted to make a library of chemical compounds by doing a michael addition of an acrylate onto some primary and secondary amines. Problem is all my amines also have thiols that I dont want to be involved in the reaction. Is it necessary to protect the thiols or can I just use the disulfide bonded version of the compounds to avoid having to protect them?
User avatar
Distinguished Member
Distinguished Member
Posts: 1425
Joined: Wed Sep 27, 2017 7:25 am
Location: Berlin, Germany

Re: Micahel addition on amines containing thiols

Post by ChenBeier »

Disulfide bonds are very weak, they break easily. I think you have to protest them.
Post Reply