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LOQ/LOD Calculations (ICP-MS)

Posted: Thu Jul 28, 2022 5:28 am
by Kupy
Good afternoon everyone,

I work in a company where we do analysis of medical material elements with ICP-MS. At the time the LOD and LOQ were calculated with the following formula.


- C1 = concentration of the high sample
- C0 = concentration of the blank
- I1 = raw intensity of the high sample (cps)
- I0 = raw intensity of the blank (cps)

I had always used a simpler formula, although it is similar. The problem is that I can't find too many references to this formula and I don't know if it appears in any Guideline.

Could someone help me?

Thank you very much!