Chemistry Forum

Does anyone have any ideas for a stepwise total synthesis of the following molecule C₃H₄NaO₇P?

Is it true that the dual carboxylate groups attached to the phosphate will retard hydrolysis in H₂O?

How can I do this?

Could it be possible to design a simple electro-chemical cell that activates the carbonyl's to kick off (OH-)'s as leaving groups and at the same time pull up the P=O double bond to create a higher electrophilicity on P that holds the other single bonded oxygen closer to P allowing for a more positive affinity on phoshpate H's to grab the recently kicked off (OH-)'s

Any insight?

Again a strange molecule. You have a combined anhydride of acetic acid , carbonic acid and phosphoric acid.
This will not exist. Carbonic acid will expell CO₂. Then we have the same molecule what you asked before.

(CH₃CO - OP(=O) - O(C=O)-OH)O- Na+
(CH₃CO - OP(=O) - OH O- Na+ + CO₂

There is no adjunct to stabilize this molecule to prevent hydrolysis and CO₂ decomposition in aqueous solution?
What about the isoelectric -HNO₃?

I know that in the biological system of humans there is an Zn based enzyme CA (carbonic anhydrase) that favors the formation of carbonic acid from H₂O and CO₂
Maybe a Zn adjunct complex would retard this decomposition?

Basically, how can this dual oxoacid chained to a mono-phosphate salt be accomplished?

R₁ O=C O-P-O C=O R₂

Should be easy right?

These compounds , if existent are only stable without of presence of water.
Other acids like nitric will destable more.
What is the purpose to synthesise this compounds?