Does anyone have any ideas for a stepwise total synthesis of the following molecule C3H4NaO7P?
Is it true that the dual carboxylate groups attached to the phosphate will retard hydrolysis in H2O?
How can I do this?
Total Synthesis
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Re: Total Synthesis
Could it be possible to design a simple electro-chemical cell that activates the carbonyl's to kick off (OH-)'s as leaving groups and at the same time pull up the P=O double bond to create a higher electrophilicity on P that holds the other single bonded oxygen closer to P allowing for a more positive affinity on phoshpate H's to grab the recently kicked off (OH-)'s
Any insight?
Any insight?
Last edited by Alexi999 on Fri Oct 22, 2021 7:57 am, edited 1 time in total.
- ChenBeier
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Re: Total Synthesis
Again a strange molecule. You have a combined anhydride of acetic acid , carbonic acid and phosphoric acid.
This will not exist. Carbonic acid will expell CO2. Then we have the same molecule what you asked before.
(CH3CO - OP(=O) - O(C=O)-OH)O- Na+
(CH3CO - OP(=O) - OH O- Na+ + CO2
This will not exist. Carbonic acid will expell CO2. Then we have the same molecule what you asked before.
(CH3CO - OP(=O) - O(C=O)-OH)O- Na+
(CH3CO - OP(=O) - OH O- Na+ + CO2
Re: Total Synthesis
There is no adjunct to stabilize this molecule to prevent hydrolysis and CO2 decomposition in aqueous solution?
What about the isoelectric -HNO3?
What about the isoelectric -HNO3?
Re: Total Synthesis
I know that in the biological system of humans there is an Zn based enzyme CA (carbonic anhydrase) that favors the formation of carbonic acid from H2O and CO2
Maybe a Zn adjunct complex would retard this decomposition?
Maybe a Zn adjunct complex would retard this decomposition?
Re: Total Synthesis
Basically, how can this dual oxoacid chained to a mono-phosphate salt be accomplished?
R1 O=C O-P-O C=O R2
Should be easy right?
R1 O=C O-P-O C=O R2
Should be easy right?
- ChenBeier
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Re: Total Synthesis
These compounds , if existent are only stable without of presence of water.
Other acids like nitric will destable more.
What is the purpose to synthesise this compounds?
Other acids like nitric will destable more.
What is the purpose to synthesise this compounds?