Why Does Glycolysis Make A Cell More Alkaline?

Chemistry and homework help forum.

Organic Chemistry, Analytical Chemistry, Biochemistry, Physical Chemistry, Computational Chemistry, Theoretical Chemistry, High School Chemistry, Colledge Chemistry and University Chemistry Forum.

Share your chemistry ideas, discuss chemical problems, ask for help with scientific chemistry questions, inspire others by your chemistry vision!

Please feel free to start a scientific chemistry discussion here!

Discuss chemistry homework problems with experts!

Ask for help with chemical questions and help others with your chemistry knowledge!

Moderators: expert, ChenBeier, Xen

Post Reply
Full Member
Full Member
Posts: 16
Joined: Sun Oct 07, 2018 7:39 pm
Location: Manila

Why Does Glycolysis Make A Cell More Alkaline?

Post by yerrag »

And why does oxidative phosphorylation make a cell more adicic?

I'm told that during glycolysis pyruvate is reduced by NADH and this turns pyruvate into lactate. NADH loses an electron and becomes NAD+.

This increases the ratio of NAD+/NADH (a redox pair).

Why does increasing the NAD+/NADH ratio make the cell more alkaline?
Warner Mortensen
Jr. Member
Jr. Member
Posts: 6
Joined: Mon Jul 26, 2021 4:13 am

Re: Why Does Glycolysis Make A Cell More Alkaline?

Post by Warner Mortensen »

Glycolysis is the process in which one glucose molecule is broken down into two 3-carbon compounds called pyruvate. Pyruvate is not reduced in glycolysis, instead glucose is reduced to pyruvate. NAD+ is the key electron carrier which reduces glucose by accepting the H+ ions and forms NADH. Since acidity of the cell is controlled by H+ ions, the cell is now slightly more alkaline as H+ ions are carried away by NADH. After glycolysis, pyruvate is only converted into lactate when there is insufficient oxygen present. When there is less oxygen, the body undergoes anaerobic respiration and pyruvate is reduced to lactate and only a small amount of ATP is produced. On the other hand, in case of aerobic respiration pyruvate goes through the Citric cycle where it is further reduced by NAD+ and FAD giving us NADH, FADH2, CO2, and GTP. During oxidative phosphorylation, the H+ ions carried by NADH and FADH2 are released making the cell more acidic. The H+ ions help in setting up the proton potential gradient with the mitochondrial matrix which is then used to produce ATP from ATP synthase. Increasing the NADH/NAD+ ratio makes the cell more alkaline simply because the number of H+ ions are reduced from the cell which are responsible for acidity.
Post Reply