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Atovaquone is an antibiotic. Sometimes it is prescribed to treat pneumocystis pneumonia (PCP, see Fact Sheet 515). It is also sometimes used to treat toxoplasmosis (See Fact Sheet 517).
Atovaquone can be given to prevent PCP or toxoplasmosis. It is also given in cases where a patient is allergic to Sulfa drugs (Bactrim or Septra) or Dapsone, or when other therapies have been ineffective.
Atovaquone is as effective as more commonly-prescribed drugs. It has fewer and different side effects. However, it is very expensive. Because of its cost, it is usually only considered for people who cannot tolerate TMP/SMX or dapsone.
Combination antiretroviral therapy (ART) can make your CD4 cell count go up. If it goes over 200 and stays there for 3 months, it may be safe to stop taking PCP medications such as atovaquone. Talk to your health care provider before discontinuing any medication.
