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by Iceeverdeen
Tue Jan 11, 2022 2:21 pm
Forum: Chemistry forum
Topic: Methylation C 2 Position imidazolium
Replies: 0
Views: 2189

Methylation C 2 Position imidazolium

Hi there,

has anyone an idea how to successfully methylate the C2 position of an imidazolium?
Tried myself the bases n-BuLi, KotBu, KHMDS and NaH with MeI as methylation agent-with either oxidation problems or minor species.