Basically, how can this dual oxoacid chained to a mono-phosphate salt be accomplished?
R1 O=C O-P-O C=O R2
Should be easy right?
Search found 13 matches
- Fri Oct 22, 2021 8:05 am
- Forum: Chemistry forum
- Topic: Total Synthesis
- Replies: 6
- Views: 3076
- Fri Oct 22, 2021 7:54 am
- Forum: Chemistry forum
- Topic: Total Synthesis
- Replies: 6
- Views: 3076
Re: Total Synthesis
I know that in the biological system of humans there is an Zn based enzyme CA (carbonic anhydrase) that favors the formation of carbonic acid from H2O and CO2
Maybe a Zn adjunct complex would retard this decomposition?
Maybe a Zn adjunct complex would retard this decomposition?
- Fri Oct 22, 2021 7:21 am
- Forum: Chemistry forum
- Topic: Total Synthesis
- Replies: 6
- Views: 3076
Re: Total Synthesis
There is no adjunct to stabilize this molecule to prevent hydrolysis and CO2 decomposition in aqueous solution?
What about the isoelectric -HNO3?
What about the isoelectric -HNO3?
- Tue Oct 19, 2021 10:06 am
- Forum: Chemistry forum
- Topic: Total Synthesis
- Replies: 6
- Views: 3076
Re: Total Synthesis
Could it be possible to design a simple electro-chemical cell that activates the carbonyl's to kick off (OH-)'s as leaving groups and at the same time pull up the P=O double bond to create a higher electrophilicity on P that holds the other single bonded oxygen closer to P allowing for a more positi...
- Tue Oct 19, 2021 9:11 am
- Forum: Chemistry forum
- Topic: Total Synthesis
- Replies: 6
- Views: 3076
Total Synthesis
Does anyone have any ideas for a stepwise total synthesis of the following molecule C3H4NaO7P?
Is it true that the dual carboxylate groups attached to the phosphate will retard hydrolysis in H2O?
How can I do this?
Is it true that the dual carboxylate groups attached to the phosphate will retard hydrolysis in H2O?
How can I do this?
- Tue Oct 19, 2021 5:31 am
- Forum: Chemistry forum
- Topic: Esterification Reaction
- Replies: 13
- Views: 5299
Re: Esterification Reaction
Thanks for you help.
- Mon Oct 18, 2021 3:03 pm
- Forum: Chemistry forum
- Topic: Esterification Reaction
- Replies: 13
- Views: 5299
Re: Esterification Reaction
Yes, can you tell me the optimal route for this chlorination, for a full synthesis.
- Mon Oct 18, 2021 11:03 am
- Forum: Chemistry forum
- Topic: Esterification Reaction
- Replies: 13
- Views: 5299
Re: Esterification Reaction
I'm just confused on how to go about this.
- Mon Oct 18, 2021 10:57 am
- Forum: Chemistry forum
- Topic: Esterification Reaction
- Replies: 13
- Views: 5299
Re: Esterification Reaction
So for example could I use sulfuric acid in aqueous solution to functionalize the carbonyl to
(CH3COOH + NaH2PO4) cat H2SO4 -> CH3CONaHPO4 +H2O
(CH3COOH + NaH2PO4) cat H2SO4 -> CH3CONaHPO4 +H2O
- Mon Oct 18, 2021 10:43 am
- Forum: Chemistry forum
- Topic: Esterification Reaction
- Replies: 13
- Views: 5299
Re: Esterification Reaction
So what if I want to use a different carboxylic acid, so what would be the system to do this
if I can't buy a chlorinated acid form?
if I can't buy a chlorinated acid form?
- Mon Oct 18, 2021 8:38 am
- Forum: Chemistry forum
- Topic: Esterification Reaction
- Replies: 13
- Views: 5299
Re: Esterification Reaction
Ok so treat the carboxylic acid with thionyl chloride ( SOCl2 ) to form the intermediate acid chloride in aqueous solution Neutralize with NaOH Then simply stoichiometrically add the disodium phosphate (Na2HPO4) Then collect precipitate final product . (What ratio of H2O to the CH3COOH do you sugges...
- Sun Oct 17, 2021 3:02 pm
- Forum: Chemistry forum
- Topic: Esterification Reaction
- Replies: 13
- Views: 5299
Re: Esterification Reaction
Thank you for the reply!
I thought that an acid anhydride is a compound that has two acyl C(O)R groups bonded to the same oxygen atom.
Thanks for the clarification. I'm still learning.
Also, what prevents di-linkage at both sodium positions of the phosphate by acetylchloride?
I thought that an acid anhydride is a compound that has two acyl C(O)R groups bonded to the same oxygen atom.
Thanks for the clarification. I'm still learning.
Also, what prevents di-linkage at both sodium positions of the phosphate by acetylchloride?
- Sun Oct 17, 2021 1:29 pm
- Forum: Chemistry forum
- Topic: Esterification Reaction
- Replies: 13
- Views: 5299
Esterification Reaction
I am interested to see if anyone knows the easiest way to mono-esterify a mono-phosphate salt group to a carboxylic acid.
How to facilitate the resultant -> product ?
CH3COOH + NaH2PO4 ‐> C2H4NaO5P
How to facilitate the resultant -> product ?
CH3COOH + NaH2PO4 ‐> C2H4NaO5P