Search found 13 matches

by Alexi999
Fri Oct 22, 2021 8:05 am
Forum: Chemistry forum
Topic: Total Synthesis
Replies: 6
Views: 2871

Re: Total Synthesis

Basically, how can this dual oxoacid chained to a mono-phosphate salt be accomplished?

R1 O=C O-P-O C=O R2

Should be easy right?
by Alexi999
Fri Oct 22, 2021 7:54 am
Forum: Chemistry forum
Topic: Total Synthesis
Replies: 6
Views: 2871

Re: Total Synthesis

I know that in the biological system of humans there is an Zn based enzyme CA (carbonic anhydrase) that favors the formation of carbonic acid from H2O and CO2
Maybe a Zn adjunct complex would retard this decomposition?
by Alexi999
Fri Oct 22, 2021 7:21 am
Forum: Chemistry forum
Topic: Total Synthesis
Replies: 6
Views: 2871

Re: Total Synthesis

There is no adjunct to stabilize this molecule to prevent hydrolysis and CO2 decomposition in aqueous solution?
What about the isoelectric -HNO3?
by Alexi999
Tue Oct 19, 2021 10:06 am
Forum: Chemistry forum
Topic: Total Synthesis
Replies: 6
Views: 2871

Re: Total Synthesis

Could it be possible to design a simple electro-chemical cell that activates the carbonyl's to kick off (OH-)'s as leaving groups and at the same time pull up the P=O double bond to create a higher electrophilicity on P that holds the other single bonded oxygen closer to P allowing for a more positi...
by Alexi999
Tue Oct 19, 2021 9:11 am
Forum: Chemistry forum
Topic: Total Synthesis
Replies: 6
Views: 2871

Total Synthesis

Does anyone have any ideas for a stepwise total synthesis of the following molecule C3H4NaO7P?

Is it true that the dual carboxylate groups attached to the phosphate will retard hydrolysis in H2O?

How can I do this?
Screenshot_20211019-104946_Molecular Constructor.jpg
Screenshot_20211019-104946_Molecular Constructor.jpg (65.99 KiB) Viewed 2871 times
by Alexi999
Tue Oct 19, 2021 5:31 am
Forum: Chemistry forum
Topic: Esterification Reaction
Replies: 13
Views: 5123

Re: Esterification Reaction

Thanks for you help. 😁
by Alexi999
Mon Oct 18, 2021 3:03 pm
Forum: Chemistry forum
Topic: Esterification Reaction
Replies: 13
Views: 5123

Re: Esterification Reaction

Yes, can you tell me the optimal route for this chlorination, for a full synthesis.
by Alexi999
Mon Oct 18, 2021 11:03 am
Forum: Chemistry forum
Topic: Esterification Reaction
Replies: 13
Views: 5123

Re: Esterification Reaction

I'm just confused on how to go about this.
by Alexi999
Mon Oct 18, 2021 10:57 am
Forum: Chemistry forum
Topic: Esterification Reaction
Replies: 13
Views: 5123

Re: Esterification Reaction

So for example could I use sulfuric acid in aqueous solution to functionalize the carbonyl to
(CH3COOH + NaH2PO4) cat H2SO4 -> CH3CONaHPO4 +H2O
by Alexi999
Mon Oct 18, 2021 10:43 am
Forum: Chemistry forum
Topic: Esterification Reaction
Replies: 13
Views: 5123

Re: Esterification Reaction

So what if I want to use a different carboxylic acid, so what would be the system to do this
if I can't buy a chlorinated acid form?
by Alexi999
Mon Oct 18, 2021 8:38 am
Forum: Chemistry forum
Topic: Esterification Reaction
Replies: 13
Views: 5123

Re: Esterification Reaction

Ok so treat the carboxylic acid with thionyl chloride ( SOCl2 ) to form the intermediate acid chloride in aqueous solution Neutralize with NaOH Then simply stoichiometrically add the disodium phosphate (Na2HPO4) Then collect precipitate final product . (What ratio of H2O to the CH3COOH do you sugges...
by Alexi999
Sun Oct 17, 2021 3:02 pm
Forum: Chemistry forum
Topic: Esterification Reaction
Replies: 13
Views: 5123

Re: Esterification Reaction

Thank you for the reply!
I thought that an acid anhydride is a compound that has two acyl C(O)R groups bonded to the same oxygen atom.

Thanks for the clarification. I'm still learning.

Also, what prevents di-linkage at both sodium positions of the phosphate by acetylchloride?
by Alexi999
Sun Oct 17, 2021 1:29 pm
Forum: Chemistry forum
Topic: Esterification Reaction
Replies: 13
Views: 5123

Esterification Reaction

I am interested to see if anyone knows the easiest way to mono-esterify a mono-phosphate salt group to a carboxylic acid.

How to facilitate the resultant -> product ?

CH3COOH + NaH2PO4 ‐> C2H4NaO5P
Screenshot_20211017-151346_Molecular Constructor.jpg
Screenshot_20211017-151346_Molecular Constructor.jpg (118.44 KiB) Viewed 5123 times