Please can someone help me solve this?

jovinovi · Post by **jovinovi** » Sun Sep 18, 2011 10:55 pm

I am trying to solve a possible reaction between chloroquine phosphate and ADP (Adenosine diphosphate) to produce ATP. My idea is that chloroquine would either act as a catalyst to produce ATP by donating itsphosphate group or it reacts directly with ADP to produce ATP. Possibly: C₁₈H₂₆ClN₃.2H₃PO₄ + C₁₀H₁₅N₅O₁₀P₂.
I'm an agriculturist in need of a real chemistry guru. Please help.

expert · Post by **expert** » Mon Sep 19, 2011 8:48 pm

Although Chloroquine binds ATP-binding cassette transporters http://en.wikipedia.org/wiki/Chloroquine it doesn’t mean that you can use it easily for making triphosphate from diphosphate. You need energy for that. Maybe in organisms it’s possible in the presence of appropriate enzymes. In vitro people usually make triphosphates from monophosphates and pyrophosphates.

jovinovi · Post by **jovinovi** » Tue Sep 20, 2011 4:27 am

thanks for your comment. I actually used it on low motility spermatozoa and it has a rejuvenating effect on them. It increases mass activity and thus progressive motility. in spermatozoa I am of the opinion the mitochondria contained in the tail piece are responsible for the energy of the spermatozoa. Since this reaction takes place in the mitochondria don't you think this is what is happening?